abstract：BACKGROUND:Acute kidney injury (AKI) is a severe disease in critically ill patients. Neutrophil infiltration into kidney was associated with the development of AKI, and P-selectin may be involved in the process of neutrophil recruitment in kidney. This study aimed to explore the potential effect of platelet-derived P-s...

journal_title：Chinese medical journal

authors： Li XH,Qian YB,Meng XX,Wang RL

更新日期：2017-07-20 00:00:00

abstract：BACKGROUND:Adenomyosis is a gynecological disorder with symptoms most presenting as dysmenorrhea and heavy menstrual bleeding. However, the presence of lower urinary tract symptoms (LUTS) among women with adenomyosis remains unclear. This study was designed to determine the prevalence of LUTS and factors related to the...

journal_title：Chinese medical journal

authors： Li T,Xu XX,Dai Y,Zhang JJ,Lang JH,Leng JH

更新日期：2017-07-05 00:00:00

abstract：BACKGROUND:Antiphospholipid syndrome (APS)-related immune factors are considered as an important cause of recurrent spontaneous abortion (RSA). Anticoagulant and anti-inflammatory treatments are believed to effectively improve adverse pregnancy outcomes by affecting the abnormal autoimmune response of the maternal-feta...

journal_title：Chinese medical journal

authors： Ye SL,Gu XK,Tao LY,Cong JM,Wang YQ

更新日期：2017-06-20 00:00:00

abstract：BACKGROUND:Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplantation. Skin barrier disruption could induce thymic stromal lymphopoietin (TSLP) expression, and the expression of TSLP was increased in lesions of atopic dermatitis (AD)-like GVHD and lichen planus (LP)-like GVHD. ...

journal_title：Chinese medical journal

authors： Li K,Mu ZL,Chen X,Wen GD,Zhao Y,Zhang JZ

更新日期：2017-06-20 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that ultrasonography is the recommended imaging modality for preoperative staging of papillary thyroid carcinomas (PTCs). However, only a few studies have kept watch on preoperative evaluation of capsular invasion (CI) or extracapsular extension (ECE) and cervical lymph nod...

journal_title：Chinese medical journal

authors： Jiao WP,Zhang L

更新日期：2017-06-05 00:00:00

abstract：BACKGROUND:Aerosolized amikacin (AA) is a current option for the management of ventilator-associated pneumonia (VAP) caused by multidrug-resistant Gram-negative bacteria (MDR-GNB), as it is reported that AA could increase the alveolar level of the drug without increasing systemic toxicity. This study aimed to evaluate ...

journal_title：Chinese medical journal

authors： Liu C,Zhang YT,Peng ZY,Zhou Q,Hu B,Zhou H,Li JG

更新日期：2017-05-20 00:00:00

abstract：BACKGROUND:Four single nucleotide polymorphisms (SNPs) in the modulator recognition factor 2/AT-rich interaction domain 5B (MRF2/ARID5B) gene located at chromosome 10q21.2 have been shown to be associated with both type 2 diabetes mellitus (T2DM) and coronary artery disease in a Japanese cohort. This study aimed to inv...

journal_title：Chinese medical journal

authors： Sun LL,Zhang SJ,Chen MJ,Elena K,Qiao H

更新日期：2017-05-05 00:00:00

abstract：BACKGROUND:Tenofovir disoproxil (TDF) is a promising salvage therapy for patients with chronic hepatitis B (CHB) who failed regimens of other nucleoside analogues (NAs). In this study, we aimed to investigate the clinical efficacy and safety of TDF monotherapy in Chinese CHB patients with genotypic resistance. METHODS...

journal_title：Chinese medical journal

authors： Zhou J,Liu YY,Lian JS,Pan LF,Yang JL,Huang JR

更新日期：2017-04-20 00:00:00

abstract：OBJECTIVE:Sepsis remains a leading cause of death in many Intensive Care Units worldwide. Immunosuppression has been a primary focus of sepsis research as a key pathophysiological mechanism. Given the important role of the negative costimulatory molecules programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD...

journal_title：Chinese medical journal

authors： Liu Q,Li CS

更新日期：2017-04-20 00:00:00

abstract：BACKGROUND:Nontraumatic spontaneous subarachnoid hemorrhage (SAH) is associated with a high mortality. This study was conducted to investigate the epidemiological features of nontraumatic spontaneous SAH in China. METHODS:From January 2006 to December 2008, the clinical data of patients with nontraumatic SAH from 32 m...

journal_title：Chinese medical journal

authors： Song JP,Ni W,Gu YX,Zhu W,Chen L,Xu B,Leng B,Tian YL,Mao Y

更新日期：2017-04-05 00:00:00

abstract：BACKGROUND:Recombinant human-erythropoietin (rh-EPO) has therapeutic efficacy for premature infants with brain damage during the active rehabilitation and anti-inflammation. In the present study, we found that the rh-EPO was related to the promotion of neovascularization. Our aim was to investigate whether rh-EPO augme...

journal_title：Chinese medical journal

authors： Yu DF,Zhu LH,Jiang L

更新日期：2017-04-05 00:00:00

abstract：BACKGROUND:Some patients with pelvic organ prolapse may suffer from lower urinary tract symptoms (LUTS), especially stress urinary incontinence (SUI) named de novo SUI after pelvic floor reconstruction. This study aimed to investigate the incidence and risk factors of de novo SUI. METHODS:This is a nested case-control...

journal_title：Chinese medical journal

authors： Wang SY,Cao TT,Wang RZ,Yang X,Sun XL,Wang JL

更新日期：2017-03-20 00:00:00

abstract：BACKGROUND:Obesity has an adverse effect on iron status. Hepcidin-mediated inhibition of iron absorption in the duodenum is a potential mechanism. Iron-deficient obese patients have diminished response to oral iron therapy. This study was designed to assess whether acupuncture could promote the efficacy of oral iron su...

journal_title：Chinese medical journal

authors： Xie XC,Cao YQ,Gao Q,Wang C,Li M,Wei SG

更新日期：2017-03-05 00:00:00

abstract：BACKGROUND:The reports on massive transfusions (MTs) in obstetrics have recently been an increasing trend. We aimed to define the clinical features, risk factors, main causes, and outcomes of MTs due to severe postpartum hemorrhage (PPH) and the frequency trends over the past 10 years. METHODS:We retrospectively analy...

journal_title：Chinese medical journal

authors： Hu J,Yu ZP,Wang P,Shi CY,Yang HX

更新日期：2017-03-05 00:00:00

abstract：BACKGROUND:The optimal timing of surgical revascularization for patients presenting with ST-segment elevation myocardial infarction (STEMI) and impaired left ventricular function is not well established. This study aimed to examine the timing of surgical revascularization after STEMI in patients with ischemic heart dis...

journal_title：Chinese medical journal

authors： Wang R,Cheng N,Xiao CS,Wu Y,Sai XY,Gong ZY,Wang Y,Gao CQ

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:Although obstructive sleep apnea (OSA) has been recognized as a major risk factor for cardiovascular complications and its clinical features are well characterized, it is difficult to replicate the OSA hypoxic model in humans. We aimed to establish an experimental rabbit model for chronic OSA and to explore ...

journal_title：Chinese medical journal

authors： Xu LF,Zhou XF,Hu K,Tang S,Luo YC,Lu W

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:Ovarian serous adenocarcinoma can be divided into low- and high-grade tumors, which exhibit substantial differences in pathogenesis, clinicopathology, and prognosis. This study aimed to investigate the differences in the PH domain leucine-rich repeat protein phosphatase (PHLPP), forkhead homeobox type O 3a (...

journal_title：Chinese medical journal

authors： Zhang J,Wang JC,Li YH,Wang RX,Fan XM

更新日期：2017-02-05 00:00:00

abstract：BACKGROUND:15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), one of the major metabolites from prostaglandin D2 in arachidonic acid metabolic pathway, has potential anti-inflammatory properties. The objective of this study was to explore the effects of 15d-PGJ2-loaded poly(D,L-lactide-co-glycolide) nanocapsules (15d-PGJ2-NC...

journal_title：Chinese medical journal

authors： Tang Q,Chen LL,Wei F,Sun WL,Lei LH,Ding PH,Tan JY,Chen XT,Wu YM

更新日期：2017-02-05 00:00:00

abstract：BACKGROUND:The molecular mechanisms of Shenxianshengmai (SXSM), a traditional Chinese medicine, on bradycardia have been incompletely understood. The study tried to investigate the gene expression profile and proteomics of bradycardia rabbits' hearts after SXSM treatment. METHODS:Twenty-four adult rabbits were randoml...

journal_title：Chinese medical journal

authors： Liu ZY,Huang J,Liu NN,Zheng M,Zhao T,Zhao BC,Wang YM,Pu JL

更新日期：2017-01-20 00:00:00

abstract：BACKGROUND:Epigallocatechin-3-gallate (EGCG) has exhibited antitumor properties in several types of cancers, including nasopharyngeal carcinoma (NPC), but the molecular mechanisms underlying this function remain incompletely understood. The aim of the present study was to characterize the global impact of EGCG on the e...

journal_title：Chinese medical journal

authors： Li BB,Huang GL,Li HH,Kong X,He ZW

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Successful antiretroviral therapy (ART) has been demonstrated to be effective in reducing the infectivity of human immunodeficiency virus (HIV). We conducted a study to predict the potential effect of ART on the spread of HIV in Chaoyang District, Beijing, China, using the Asian Epidemic Model (AEM). METHOD...

journal_title：Chinese medical journal

authors： Tao LL,Liu M,Li SM,Liu J,Jiang SL,Wang LJ,Luo FJ,Wang N

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The effectiveness of neoadjuvant chemoradiotherapy (NCRT) treatment for patients with esophageal carcinoma (EC) remains controversial. The aim of this study was to compare the effect of NCRT followed by surgery (NCRTS) with surgery alone (SA) for EC. METHODS:The PubMed, EMBASE, and the Cochrane Library data...

journal_title：Chinese medical journal

authors： Wang DB,Sun ZY,Deng LM,Zhu DQ,Xia HG,Zhu PZ

更新日期：2016-12-20 00:00:00

abstract：BACKGROUND:The medium-to-long-term use of antimuscarinics alone or in combination with an α-blocker in men with an enlarged prostate is still controversial. This double-blind, placebo-controlled, randomized clinical trial aimed to investigate the efficacy and safety of medium-to-long-term use of tolterodine extended re...

journal_title：Chinese medical journal

authors： Cai JL,Zhou Z,Yang Y,Yan YF,Jing S,Na YQ

更新日期：2016-12-20 00:00:00

abstract：BACKGROUND:The prognostic values of the coronary computed tomography angiography (CCTA) score for predicting future cardiovascular events have been previously demonstrated in numerous studies. However, few studies have used the rich information available from CCTA to detect functionally significant coronary lesions. We...

journal_title：Chinese medical journal

authors： Zhang C,Yang S,Gai LY,Han ZQ,Xin Q,Yang XB,Yang JJ,Jin QH

更新日期：2016-12-05 00:00:00

abstract：BACKGROUND:Amyloid β (Aβ) deposits and the endoplasmic reticulum stress (ERS) are both well established in the development and progression of Alzheimer's disease (AD). However, the mechanism and role of Aβ-induced ERS in AD-associated pathological progression remain to be elucidated. METHODS:The five familial AD (5×FA...

journal_title：Chinese medical journal

authors： Shen H,Pan XD,Zhang J,Zeng YQ,Zhou M,Yang LM,Ye B,Dai XM,Zhu YG,Chen XC

更新日期：2016-12-05 00:00:00

abstract：BACKGROUND:Among HIV-infected patients initiating antiretroviral therapy (ART), early changes in CD4+ T-cell subsets are well described. However, HIV-infected late presenters initiating treatment present with a suboptimal CD4+ T-cell reconstitution and remain at a higher risk for AIDS and non-AIDS events. Therefore, fa...

journal_title：Chinese medical journal

authors： Guo FP,Li YJ,Qiu ZF,Lv W,Han Y,Xie J,Li YL,Song XJ,Du SS,Mehraj V,Li TS,Routy JP

更新日期：2016-11-20 00:00:00

abstract：BACKGROUND:After total hip arthroplasty (THA), there is a noteworthy inflammatory response. The inflammatory response is associated with postoperative recovery and complications. However, there had been few reports on the relationship between inflammatory response and postoperative complication rate. The aim of the pre...

journal_title：Chinese medical journal

authors： Chen XX,Wang T,Li J,Kang H

更新日期：2016-11-05 00:00:00

abstract：BACKGROUND:Dry eye patients suffer from all kinds of symptoms. Sometimes, the clinical signs evaluation does not disclose any obvious difference in routine examination; in vivo confocal microscopy (IVCM) is a powerful tool for ocular surface disease. This study aimed to clarify meibomian gland (MG) alterations in dry e...

journal_title：Chinese medical journal

authors： Zhao H,Chen JY,Wang YQ,Lin ZR,Wang S

更新日期：2016-11-05 00:00:00

abstract：BACKGROUND:The most typical cardiac abnormality is conotruncal defects (CTDs) in patients with 22q11 deletion syndrome (22q11DS). HIRA (histone cell cycle regulator) gene, as one of the candidate genes located at the critical region of 22q11DS, was reported as possibly relevant to CTD in animal models. This study aimed...

journal_title：Chinese medical journal

authors： Ju ZR,Wang HJ,Ma XJ,Ma D,Huang GY

更新日期：2016-10-20 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is a heterogeneous disease; current research relies on cancer cell lines and animal cancer models, which may not precisely imitate inner human tumors and guide clinical medicine. The purpose of our study was to explore and further improve the process of producing three-dimensional (3D...

journal_title：Chinese medical journal

authors： Xie BY,Wu AW

更新日期：2016-10-20 00:00:00

abstract：BACKGROUND:The efficacy of percutaneous intradiscal radiofrequency thermocoagulation (PIRFT) for the treatment of discogenic low back pain (LBP) remains controversial. However, all the PIRFT studies utilized monopolar radiofrequency thermocoagulation (RFTC). The aim of this study was to investigate the safety and effic...

journal_title：Chinese medical journal

authors： Zhang L,Ding XL,Zhao XL,Wang JN,Li YP,Tian M

更新日期：2016-10-05 00:00:00

abstract：BACKGROUND:The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the effects of long-term exposure to traffic-related air pollution on lung function, airway inflammation, and respiratory symptoms. METHODS:We enrolled 1003 residents aged 57.96 ± 8.99 years livi...

journal_title：Chinese medical journal

authors： Hu ZW,Zhao YN,Cheng Y,Guo CY,Wang X,Li N,Liu JQ,Kang H,Xia GG,Hu P,Zhang PJ,Ma J,Liu Y,Zhang C,Su L,Wang GF

更新日期：2016-09-20 00:00:00

abstract：BACKGROUND:Urine output (UO) is an essential criterion of the Kidney Disease Improving Global Outcomes (KDIGO) definition and classification system for acute kidney injury (AKI), of which the diagnostic value has not been extensively studied. We aimed to determine whether AKI based on KDIGO UO criteria (KDIGOUO) could ...

journal_title：Chinese medical journal

authors： Qin JP,Yu XY,Qian CY,Li SS,Qin TH,Chen EZ,Lin JD,Ai YH,Wu DW,Liu DX,Sun RH,Hu ZJ,Cao XY,Zhou FC,He ZY,Zhou LH,An YZ,Kang Y,Ma XC,Zhao MY,Jiang L,Xu Y,Du B,China Critical Care Clinical Trial Group (CCCCTG).

更新日期：2016-09-05 00:00:00

abstract：BACKGROUND:The offspring of women with gestational diabetes mellitus (GDM) are prone to macrosomia. However, birth weight is difficult to be correctly estimated by ultrasound because of fetal asymmetric growth characteristics. This study aimed to investigate the correlations between fetal hemodynamics, fetal growth ind...

journal_title：Chinese medical journal

authors： Liu F,Liu Y,Lai YP,Gu XN,Liu DM,Yang M

更新日期：2016-09-05 00:00:00

abstract：BACKGROUND:Mitochondrial diseases are a group of energy metabolic disorders with multisystem involvements. Variable clinical features present a major challenge in pediatric diagnoses. We summarized the clinical spectrum of m.3243A>G mutation in Chinese pediatric patients, to define the common clinical manifestations an...

journal_title：Chinese medical journal

authors： Xia CY,Liu Y,Liu H,Zhang YC,Ma YN,Qi Y

更新日期：2016-08-20 00:00:00

abstract：BACKGROUND:Collagen VI-related myopathies are autosomal dominant and recessive hereditary myopathies, mainly including Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM). Muscle magnetic resonance imaging (MRI) has been widely used to diagnosis muscular disorders. The purpose of this study was to ev...

journal_title：Chinese medical journal

authors： Fu J,Zheng YM,Jin SQ,Yi JF,Liu XJ,Lyn H,Wang ZX,Zhang W,Xiao JX,Yuan Y

更新日期：2016-08-05 00:00:00

abstract：BACKGROUND:Over the years, the mechanical ventilation (MV) strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation (LPV), among brain-injured patients in China. METHODS:This study was a multicenter, 1-day, cross-sectional study in...

journal_title：Chinese medical journal

authors： Luo XY,Hu YH,Cao XY,Kang Y,Liu LP,Wang SH,Yu RG,Yu XY,Zhang X,Li BS,Ma ZX,Weng YB,Zhang H,Chen DC,Chen W,Chen WJ,Chen XM,Du B,Duan ML,Hu J,Huang YF,Jia GJ,Li LH,Liang YM,Qin BY,Wang XD,Xiong J,Yan LM

更新日期：2016-07-20 00:00:00

abstract：:[This corrects the article DOI: 10.4103/0366-6999.181956.]. ...

journal_title：Chinese medical journal

authors：

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:The Notch-regulated ankyrin repeat protein (NRARP) is recently found to promote proliferation of breast cancer cells. The role of NRARP in carcinogenesis deserves extensive investigations. This study attempted to investigate the expression of NRARP in thyroid cancer tissues and assess the influence of NRARP ...

journal_title：Chinese medical journal

authors： Chu BF,Qin YY,Zhang SL,Quan ZW,Zhang MD,Bi JW

更新日期：2016-07-05 00:00:00

abstract：BACKGROUND:Image-guided radiation therapy (IGRT) is the preferred method for curative treatment of localized prostate cancer, which could improve disease outcome and reduce normal tissue toxicity reaction. IGRT using cone-beam computed tomography (CBCT) in combination with volumetric-modulated arc therapy (VMAT) potent...

journal_title：Chinese medical journal

authors： Li M,Li GF,Hou XY,Gao H,Xu YG,Zhao T

更新日期：2016-06-20 00:00:00